Featured Company News - ContraVir Announces Issuance of New US Patent for Expansion of Cyclophilin Inhibitor Program
Research Desk Line-up: Akebia Therapeutics Post Earnings Coverage
LONDON, UK / ACCESSWIRE / August 23, 2017 /Pro-Trader Daily takes a look at the latest corporate events and news making the headlines for Edison based ContraVir Pharmaceuticals, Inc. (NASDAQ: CTRV) ("ContraVir"), following which we have published a free report that can be viewed by signing up at http://protraderdaily.com/optin/?symbol=CTRV. The Company announced on August 21, 2017, the issuance of a new patent, US 9,714,271 by the United States Patent and Trademark Office (USPTO), covering a broad collection of cyclophilin inhibitors. ContraVir anticipates that CRV431, the Company's lead cyclophilin inhibitor for use as an antiviral which is being developed for the treatment of hepatitis B virus (HBV), will be used in conjunction with tenofovir exalidex (TXLTM), its lead drug currently in Phase-2 clinical trials. For immediate access to our complimentary reports, including today's coverage, register for free now at:
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Issuance of New Patent helps ContraVir to Expand beyond HBV Core Program
Commenting on the issuance, James Sapirstein, Chief Executive Officer of ContraVir, stated that the Company is pleased to have received the issuance of this additional patent, as it provides broad coverage of many compounds within its library of cyclophilin inhibitors. This also positions ContraVir for opportunities to potentially treat other diseases. He added that having a patented portfolio of cyclophilin inhibitors allows the Company to access additional disease indications and potentially expand beyond its core program in HBV.
ContraVir Provided Insights into MOA of its HBV-Optimized CRV431
The news release states that on April 04, 2017, ContraVir provided new insights into the mechanism of action (MOA) of its hepatitis B virus (HBV)-optimized cyclophilin inhibitor CRV431. Studies showed that CRV431 potently blocks the interaction between hepatitis B surface antigen (HBsAg), a key HBV protein, and cyclophilin A, an important cellular protein. The findings further elucidated the MOA of CRV431, and supported the Company's strategy of providing a functional cure, where HBV remained suppressed following the completion of drug treatment.
About Cyclophilin Inhibitors
Cyclophilins constitute one of the three families of peptidyl prolyl isomerase enzymes. Different types of cyclophilins are ubiquitous and differ in their cellular localization, enzymatic properties, and their role in protein folding, and play a key role in many diverse diseases including infectious diseases, inflammation, cell death, muscular dystrophy, ischemia reperfusion, and oncogenesis. Cyclophilin inhibitors are being developed to treat neurodegenerative diseases.
CRV431 belongs to a known drug class of cyclophilin inhibitors derived from cyclosporine A, and was designed specifically to optimize potency and selectivity against HBV, a hepatitis B virus that affects the liver and occurs in both acute and chronic modalities. CRV431 shows potential in experimental models to complement current hepatitis B treatments by reducing multiple markers of infection including HBV DNA, HBsAg, HBx, HBeAg, and HBV uptake by cells.
About ContraVir Pharmaceuticals, Inc.
Founded in 2013, ContraVir is a biopharmaceutical company focused on the development and commercialization of targeted antiviral therapies, specifically for the treatment of HBV infections. The Company is developing two novel anti-HBV compounds with complementary mechanisms of action. TXL™ currently in Phase-2a, is designed to deliver high intrahepatic concentrations of TFV, while minimizing off-target effects caused by high levels of circulating TFV. CRV431, the other anti-HBV compound, is a next-generation cyclophilin inhibitor with a unique structure that increases its potency and selective index against HBV.
Last Close Stock Review
At the close of trading session on Tuesday, August 22, 2017, ContraVir Pharma's stock price declined 6.16% to end the day at $0.54. A total volume of 886.22 thousand shares were exchanged during the session, which was above the 3-month average volume of 513.86 thousand shares. At Tuesday's closing price, the stock's net capitalization stands at $39.86 million.
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