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Senhwa Biosciences Announces Abstract Accepted for Presentation at the 2022 ASCO Gastrointestinal Cancers Symposium

News Provided by PR Newswire2021-11-15
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Senhwa Biosciences Announces Abstract Accepted for Presentation at the 2022 ASCO Gastrointestinal Cancers Symposium

 
[15-November-2021]
 

TAIPEI and SAN DIEGO, Nov. 15, 2021 /PRNewswire/ -- Senhwa Biosciences, Inc. (TPEx: 6492), a drug development company focusing on first-in-class therapeutics for oncology, rare diseases, and novel coronaviruses, announced that an abstract highlighting clinical design for their lead drug candidate, Pidnarulex (CX-5461), in patients with solid tumors and BRCA2 and/or PALB2 mutation, has been accepted for trial in progress poster presentation at the upcoming American Society of Clinical Oncology Gastrointestinal Cancers Symposium (2022 ASCO GI) in San Francisco, 20-22 January, 2022.

(PRNewsfoto/Senhwa Biosciences, Inc.)

Inherited mutations in BRCA genes predispose to various early onset cancers. Approximately 10% and 19% of pancreatic cancer patients harboring BRCA1 and BRCA2 mutations respectively and FDA has approved Lynparza (olaparib), the first poly ADP-ribose polymerase inhibitor (PARPi) as frontline maintenance in pancreatic cancer in late 2019. Unfortunately, resistance to PARPi associated with multiple mechanisms can be observed over time, suggesting a prominent unmet need for the development of new treatment options.

"Pidnarulex alone, has shown efficacy in tumor cells resistant to PARPi in the preclinical studies. When Pidnarulex was in combination with other chemotherapeutics, it even delayed the development of PARPi resistance. Therefore, we believe Pidnarulex demonstrates great potential as a treatment for pancreatic or other cancer patients who have acquired resistance to PARPi or other chemotherapies," said Tai-Sen Soong, Chief Executive Officer of Senhwa Biosciences.

The full abstract will be made available online via https://meetinglibrary.asco.org at 5:00 PM (EST) on 18 January, 2022.

About Pidnarulex (CX-5461)

Specific mutations within the Homologous Recombination (HR) pathway may be exploited by Pidnarulex through a "synthetic lethality" approach by targeting the DNA repair defects in HR Deficient tumors. Specifically, Pidnarulex is designed to stabilize DNA G-quadruplexes of cancer cells, which leads to disruption of the cell's replication fork. While acting in concert with HR pathway deficiencies, such as BRCA1/2 mutations, replication forks stall and cause DNA breaks, ultimately resulting in cancer cell death. On the other hand, PMCC postulates a different mechanism of action. Specifically, it is thought that Pidnarulex acts as a RNA Pol I Inhibitor.

About Senhwa Biosciences

Senhwa Biosciences, Inc. is a leading clinical-stage company focused on developing first-in-class, next-generation DNA damage response therapeutics for patients with unmet medical needs in oncology. Headquartered in Taiwan, with an operational base in San Diego, California, Senhwa is well-positioned to oversee the development of its compounds.
 
Development is currently focused on two lead drug candidates, Silmitasertib (CX-4945) and Pidnarulex (CX-5461), both with novel mechanisms of action as anti-cancer drugs for multiple indications. Clinical trials are currently ongoing in Australia, Canada, United States, South Korea, and Taiwan. 

Visit Senhwa Biosciences website for more details: www.senhwabio.com

Cision View original content to download multimedia:https://www.prnewswire.com/news-releases/senhwa-biosciences-announces-abstract-accepted-for-presentation-at-the-2022-asco-gastrointestinal-cancers-symposium-301423756.html

SOURCE Senhwa Biosciences, Inc.


Company Codes: Gretai:6492


© 2021 PR Newswire. All Rights Reserved.

The news, reports, views and opinions of authors (or source) expressed are their own and do not necessarily represent the views of CRWE World.


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