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Therapeutic Solutions International Releases "IsoStilbene" Injectable Formulation of Pterostilbene Under Granted Patent for Augmentation of Immunotherapy and Targeting of Cancer Stem Cells

News Provided by GlobeNewswire2018-06-25

IsoStilbene to be Included in Pan American Cancer Treatment Center Protocols

OCEANSIDE, Calif., June 25, 2018 (GLOBE NEWSWIRE) -- Via OTC PR Wire -- Therapeutics Solutions International, Inc., (OTC Markets:TSOI) announced today the formulation and initial clinical implementation of an injectable form of pterostilbene called "IsoStilbene derived from their '047 patent."

As previously announced TSOI has licensed its entire StemVacs Platform that includes our peptide pulsed dendritic cell vaccine (StemVacs), innaMune, MemoryMune, LymphoBoost, and NanoStilbene to Pan American Cancer Center ("Pan Am") in Tijuana Mexico.

"In adding IsoStilbene, an injectable formulation of pterostilbene, to Pan Am' arsenal of immuno-therapeutics, they now have the ability to provide booster dosing of pterostilbene to supplement the 10ml daily intake of NanoStilbene patients already receive as part of their overall treatment, by providing IsoStilbene intravenously," said Timothy Dixon, President and CEO of Therapeutic Solutions International. "This is now the fourth commercial product derived from the issued '047 patent and we are very excited to offer this to Pan Am as well," added Mr. Dixon.

Peer reviewed publications have demonstrated efficacy of the pterostilbene molecule at stimulating immunity to cancer, as well as targeting cancer stem cells1,2. Unfortunately, classical formulations of pterostilbene do not appear to deliver effective amounts of pterostilbene to cancer cells. For this reason, Therapeutic Solutions International has developed several alternative dosing formulations including the previously disclosed NanoStilbene, and now, IsoStilbene.

"Pterostilbene is a highly potent analogue of resveratrol, which has been shown by multiple investigators to possess therapeutic benefits in a variety of models of cancer. The current progress by the Company, combined with collaborators at the Pan Am Cancer Treatment Center, allows for rapid translation of these non-toxic cancer immunotherapeutic approaches to the clinic," said James Veltmeyer, MD, Chief Medical Officer of TSOI.Â

1 Huang et al. Modulation of macrophage polarization and lung cancer cell stemness by MUC1 and development of a related small-molecule inhibitor pterostilbene. Oncotarget. 2016 Jun 28;7(26):39363-39375. http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=8101&pubmed-linkout=1

2 Mak et al. Pterostilbene, a bioactive component of blueberries, suppresses the generation of breast cancer stem cells within tumor microenvironment and metastasis via modulating NF-B/microRNA 448 circuit. Mol Nutr Food Res. 2013 Jul;57(7):1123-34. https://www.ncbi.nlm.nih.gov/pubmed/23504987

About Therapeutic Solutions International, Inc.
Therapeutic Solutions International is focused on immune modulation for the treatment of several specific diseases. Immune modulation refers to the ability to upregulate (make more active) or downregulate (make less active) one's immune system. The Company's corporate website is www.therapeuticsolutionsint.com.

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