Mallinckrodt Announces Real World Data on Hepatorenal Syndrome (HRS) and Acute Kidney Injury (AKI) in Patients with Liver Disease at The Liver Meeting Digital Experience
Mallinckrodt Announces Real World Data on Hepatorenal Syndrome (HRS) and Acute Kidney Injury (AKI) in Patients with Liver Disease at The Liver Meeting Digital Experience Advancing American kidney health has been identified as a key public health priority by a 2019 Presidential Executive Order |
[16-November-2020] |
DUBLIN, Nov. 16, 2020 /PRNewswire/ -- Mallinckrodt plc, a global biopharmaceutical company, today announced findings from a large U.S. database review of patient profiles and outcomes of patients hospitalized with hepatorenal syndrome (HRS) and acute kidney injury (AKI). The descriptive data on HRS and AKI patients with liver disease may help advance kidney health, aligned with a recent U.S. Executive Order (No. 13879). Findings were presented during a poster presentation at The Liver Meeting Digital Experience, the annual meeting of the American Association for the Study of Liver Diseases (AASLD). The poster can be accessed here on the company's website. HRS is a life-threatening complication that may occur in patients with advanced liver disease.1 HRS is classified into two distinct types – hepatorenal syndrome type-1 and type-2.1 Hepatorenal syndrome type 1 (HRS-1) is a rapidly progressive condition that leads to renal failure.1 It is often a challenge to effectively diagnose in a timely manner due to its diagnosis of exclusion.2 The Premier Healthcare Database, a U.S. hospital-based database with over 1,000 contributing hospitals, was used to identify adult patients with an International Classification of Diseases diagnosis of HRS or AKI and liver cirrhosis in 2017 and 2018. A total of 54,945 patients met study inclusion criteria, including 13,061 patients in the HRS cohort and 41,884 in the AKI cohort. Majority of the patients (90.2 percent) in the HRS cohort also had an AKI diagnosis. Comparing the HRS and AKI cohorts, in-hospital mortality rates were 26.4 percent versus 9.1 percent, respectively.3 Hospice discharge rates and proportion discharged home or self-care were 19 percent and 21.4 percent in the HRS cohort and 6.9 percent and 39.2 percent in the AKI cohort. Between the HRS and AKI cohorts, the average hospital length of stay was 10.9 versus 8.1 days.3 "Hepatorenal syndrome is difficult to diagnose and typically met with high mortality rates if left untreated. Identifying the disease from a large national hospital database, although with limitations, is important as it enables us to understand national practice patterns and outcomes," said Andrew Allegretti, M.D. MSc, Director of Critical Care Nephrology, Massachusetts General Hospital. "The descriptive data from this study may help advance kidney health in line with a 2019 Executive Order and may help support future research to help identify healthcare resource utilization and costs in this population." HRS-1 has a median survival time of approximately two weeks and greater than 80 percent mortality within three months if left untreated.2,4 At present, there are no drug therapies approved for the treatment of HRS-1 in the U.S. or Canada.5 HRS-1 is estimated to affect between 30,000 and 40,000 patients in the U.S. annually.6,7 "The work of Dr. Allegretti and his team around hepatorenal syndrome, and more specifically HRS-1, helps us better understand this complex disease and the potential costs that may be associated with it," said George Wan, Ph.D., MPH, Vice President, Global Head of Health Economics and Outcomes Research at Mallinckrodt Pharmaceuticals. The study was funded by Mallinckrodt. ABOUT MALLINCKRODT Mallinckrodt uses its website as a channel of distribution of important company information, such as press releases, investor presentations and other financial information. It also uses its website to expedite public access to time-critical information regarding the company in advance of or in lieu of distributing a press release or a filing with the U.S. Securities and Exchange Commission (SEC) disclosing the same information. Therefore, investors should look to the Investor Relations page of the website for important and time-critical information. Visitors to the website can also register to receive automatic e-mail and other notifications alerting them when new information is made available on the Investor Relations page of the website. CAUTIONARY STATEMENTS RELATED TO FORWARD-LOOKING STATEMENTS CONTACT Media Inquiries Investor Relations Mallinckrodt, the "M" brand mark and the Mallinckrodt Pharmaceuticals logo are trademarks of a Mallinckrodt company. Other brands are trademarks of a Mallinckrodt company or their respective owners. © 2020 Mallinckrodt. US-1901525 11/20 References 1 National Organization for Rare Disorders. Hepatorenal Syndrome. Available at: https://rarediseases.org/rare-diseases/hepatorenal-syndrome/. Accessed November 3, 2020. View original content to download multimedia:http://www.prnewswire.com/news-releases/mallinckrodt-announces-real-world-data-on-hepatorenal-syndrome-hrs-and-acute-kidney-injury-aki-in-patients-with-liver-disease-at-the-liver-meeting-digital-experience-301173287.html SOURCE Mallinckrodt plc | ||
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