Tresiba® demonstrated significantly improved blood sugar control and lower rates of hypoglycemia versus insulin Toujeo® in real-world evidence study
Tresiba® demonstrated significantly improved blood sugar control and lower rates of hypoglycemia versus insulin Toujeo® in real-world evidence study |
[23-June-2018] |
Adults with type 2 diabetes treated with Tresiba® (insulin degludec injection) had a significant reduction in HbA1c and a 30 per cent lower rate of hypoglycemic episodes compared with those treated with Toujeo® (insulin glargine U300) after starting basal insulin TORONTO, June 23, 2018 /CNW/ - Findings from CONFIRM – a large real-world evidence (RWE) study comparing the effectiveness of Tresiba® (insulin degludec injection) versus Toujeo® (insulin glargine U300) – will be presented on Monday, June 25, 2018 at the American Diabetes Association's 78th Scientific Sessions (ADA) in Orlando, US. The retrospective, non-interventional comparative effectiveness study, which included more than 4,000 adults with type 2 diabetes who were starting basal insulin for the first time, showed that after six months those treated with Tresiba® had significantly lower HbA1c compared to those treated with Toujeo® (-1.5 per cent vs. -1.2 per cent respectively; p=0.029).1 As a secondary endpoint, there was a 30 per cent lower rate of hypoglycemic episodes with Tresiba® compared to Toujeo® (p=0.045).1 In this study, hypoglycemic events, ranging from mild to severe, were registered using the International Classification of Diseases (ICD) codes 9/10 following diagnosis from a physician.2 This real world study also showed in another secondary endpoint that people treated with Tresiba® were more likely to stay on their treatment. Those treated with Toujeo® had a 37 per cent higher rate of discontinuing treatment after two years (p<0.001).1 "Real-world studies are important to understanding how clinical trials may translate into real value for patients in everyday clinical practice," said Todd Hobbs, vice president and US chief medical officer of Novo Nordisk. "The CONFIRM results add to the body of evidence on Tresiba® for adults with type 2 diabetes." About the CONFIRM study Patients were uncontrolled on one or more oral antidiabetic drugs or a GLP-1 (glucagon-like peptide-1 receptor agonist) and prescribed Tresiba® or Toujeo® according to local practice. Electronic health records were sourced from multiple health systems in the U.S. The primary endpoint was change in HbA1c (blood sugar control) from baseline to six months follow-up. Secondary endpoints included rate of hypoglycemia, proportion of patients with at least one hypoglycemia episode and the rate of treatment discontinuation. As with all real-world studies, CONFIRM was not randomised and it carries the limitations of real-world evidence. This includes potential under-reporting of hypoglycaemia (however, this is the case in both treatment arms in CONFIRM meaning that the rate ratio as well as the odds ratio are expected to be preserved), and the short follow-up period of 3-6 months (though this corresponds to when the largest changes in HbA1c tend to occur and is commonly used in many trials). Additionally, in CONFIRM there is only evidence of prescribed basal insulin and not actual use (whether the medication was picked up at the pharmacy). About hypoglycemia About Tresiba® About Novo Nordisk References
SOURCE Novo Nordisk Canada Inc. | ||
Company Codes: NYSE:NVO |
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