Novasight™ Hybrid Imaging System Featured in Published JSCAI Case Report Demonstrating Superior Diagnosis and Precision-Guided Therapy in Complex Coronary Case
TORONTO, July 30, 2025 (GLOBE NEWSWIRE) -- Conavi Medical Inc. (TSXV: CNVI) (OTCQB: CNVIF), a leader in hybrid intravascular imaging, is pleased to announce the publication of a compelling case report in the Journal of the Society for Cardiovascular Angiography & Interventions (JSCAI) highlighting the clinical impact of the Company’s Novasight™ Hybrid IVUS-OCT System in guiding accurate diagnosis and optimal stent placement in a complex coronary artery case. The case was performed, and the images were collected using the first-generation Novasight Hybrid IVUS-OCT system.
“This publication validates our belief that hybrid imaging is the future of precision-guided interventional cardiology,” said Thomas Looby, CEO of Conavi Medical. “Our goal is to help physicians make faster, more accurate decisions and ultimately improve patient outcomes. Also, this article is based on the first-generation system. We are especially excited about our next-generation Novasight™ Hybrid System, which is designed to deliver enhanced image quality and functionality for even greater physician and patient benefit, and the U.S. FDA 510(k) submission is on track for Q3 2025.”
The report, titled “The Role of Comprehensive Hybrid Imaging in Identification of Plaque Rupture and Ostial Stent Placement: Case Report” (DOI: 10.1016/j.jscai.2025.103814), details the treatment of a 52-year-old male patient with multiple cardiovascular risk factors, including diabetes, hypertension, hyperlipidemia, and end-stage renal disease. Initial angiography suggested a calcified lesion at the ostium of the right coronary artery (RCA). However, hybrid imaging using the Novasight™ System, integrating both intravascular ultrasound (IVUS) and optical coherence tomography (OCT), revealed the true culprit: a plaque rupture, not significant calcification.
“Hybrid imaging has the power to transform how we diagnose and treat complex coronary disease,” said Dr. Megha Prasad, co-author of the study and interventional cardiologist. “In this patient, angiography alone could have potentially led us down the wrong path. The ability to combine the high-resolution structural detail of OCT with the anatomical reference points of IVUS in real time allowed us to correctly identify the plaque rupture and precisely treat the lesion, something neither modality could have done alone.”
The case demonstrates how the simultaneous use of intravascular ultrasound (IVUS) and optical coherence tomography (OCT) via the Novasight Hybrid catheter enabled physicians to:
- Correctly identify a plaque rupture previously mischaracterized as calcification by angiography alone
- Leverage OCT’s high-resolution imaging to visualize intraplaque hemorrhage and rupture cavity
- Use IVUS to mark and visualize the coronary ostium with precision, allowing for accurate stent placement and optimal expansion
The publication reinforces the Novasight™ System’s role in aligning with new U.S. imaging Class 1A Guidelines for intracoronary imaging and Acute Coronary Syndrome (ACS) that advocate for broader use of intracoronary imaging in PCI. Conavi’s hybrid solution uniquely addresses long-standing barriers to adoption, including the need for separate imaging systems and interpretation challenges, particularly among less experienced operators.
Figure 1: Before percutaneous coronary intervention
(A) Angiogram of right coronary artery (RCA) lesion; intravenous ultrasound (top) and optical coherence tomography (bottom) visualizations of (B) ostial RCA, (C) conus branch, (D) intraplaque hemorrhage and wire artifact, (E) plaque rupture cavity and wire artifact, and (F) distal reference
Figure 2: After percutaneous coronary intervention
(A) Angiogram of right coronary artery (RCA) lesion; intravenous ultrasound (top) and optical coherence tomography (bottom) visualizations of (B) proximal edge of stent struts of ostial RCA (demonstrating no extension into the aorta), (C) minimal stent area of 9.40 mm2, (D) distal stent edge struts and wire artifact, and (E) the distal reference.
About Conavi Medical Corp.:
Conavi Medical is focused on designing, manufacturing, and marketing imaging technologies to guide common minimally invasive cardiovascular procedures. Its patented Novasight Hybrid™ System is the first system to combine both intravascular ultrasound (IVUS) and optical coherence tomography (OCT) to enable simultaneous and co-registered imaging of coronary arteries. The Novasight Hybrid System has 510(k) clearance from the U.S. Food and Drug Administration; and regulatory approval for clinical use from Health Canada, China 's National Medical Products Administration, and Japan 's Ministry of Health, Labor and Welfare. For more information, visit conavi.com.
Cautionary Statement Regarding Forward-Looking Information
This news release contains “forward-looking statements” within the meaning of applicable Canadian and U.S. securities laws, which reflect the current expectations of management of Conavi’s future growth, results of operations, performance and business prospects and opportunities. Forward-looking statements are frequently, but not always, identified by words such as “may”, “would”, “could”, “will”, “anticipate”, “believe”, “plan”, “expect”, “intend”, “estimate”, “potential for” and similar expressions, although these words may not be present in all forward-looking statements. Forward-looking statements that appear in this release may include, without limitation, references to Conavi’s plans for the commercialization of its Novasight Hybrid™ System.
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