| - Endo is the first pharmaceutical company to launch an external spatial computing program.
- The Spatial Computing Injection Simulator allows hand specialists to interact simultaneously with both physical and digital objects—blending a physical hand model and digital content via an Apple Vision Pro app—to help refine their injection technique.
- All members of Endo's orthopedics sales team are able to offer the experience to healthcare providers. MALVERN, Pa., March 26, 2025 /PRNewswire/ -- Endo, Inc. (OTCQX: NDOI) announced today the launch of a first-of-its-kind initiative for a pharmaceutical company: the Spatial Computing Injection Simulator. The simulator leverages the power of spatial computing (also called "mixed reality") to augment a fully immersive learning environment for healthcare providers on Apple Vision Pro. Experience the interactive Multimedia News Release here: https://www.multivu.com/endo/9322451-en-endo-launches-spatial-computing-injection-simulator-for-xiaflex "The Spatial Computing Injection Simulator represents a major leap forward in enhancing patient care through a groundbreaking educational tool," said Justin Mattice, Senior Vice President & General Manager, Branded Specialty at Endo. "We're proud to pioneer this capability in the pharmaceutical industry, paving the way for future innovations that will help transform how healthcare professionals learn and gain hands-on experience." Endo designed the Spatial Computing Injection Simulator to help hand specialists refine their injection technique in the hand for the administration of XIAFLEX® (collagenase clostridium histolyticum), the only FDA-approved nonsurgical treatment for Dupuytren's contracture when a "cord" can be felt. Do not receive XIAFLEX® if you have had an allergic reaction to collagenase clostridium histolyticum or any of the ingredients in XIAFLEX®, or to any other collagenase product. The Experience
The Spatial Computing Injection Simulator allows providers to interact with both physical objects and digital content simultaneously via a lifelike hand simulator model and an Apple Vision Pro app. During the immersive, 20-minute experience, hand specialists receive "hands on" practice on reconstitution and injection angles, watch procedures in action, practice their injection technique on the hand model, and acquire information on the post-injection process. This can help them refine their technique for the treatment of real patients with XIAFLEX, which is injected into the collagen "cord" causing the hand contracture.1 XIAFLEX represents an important treatment option to help appropriate patients.1 Early Reactions and Reviews
Endo recently previewed the technology at two premier medical conferences and generated interest and buzz for the program. At both the American Society for Surgery of the Hand (ASSH) and American Association for Hand Surgery (AAHS) annual meetings, healthcare providers lined up to try on the headsets and test their injection technique. In total, more than 600 hand specialists used the Spatial Computing Injection Simulator during the previews. "Technology like this can make a huge difference for a hand surgeon or advanced practice provider in treating Dupuytren's contracture nonsurgically," said Dr. Jason Fanuele, an orthopedic surgeon who specializes in hand and upper extremity. "In my practice, we value a hands-on approach to learning, and this is the next-best thing to actually doing an injection in someone's hand—maybe even better thanks to the educational resources and context." Now, all members of Endo's orthopedics sales team are able to offer the experience to healthcare providers. Endo worked with technology agency Lucid Dream to create the Apple Vision Pro app and spatial computing experience. About Dupuytren's Contracture
Dupuytren's contracture is a lifelong condition that may get worse over time. It's caused by a buildup of collagen in the hand, which forms a rope-like cord that pulls fingers toward the palm so they can't be straightened. As Dupuytren's contracture progresses, it may become difficult for individuals to use their hand(s) for daily tasks and activities.2,3 Dupuytren's contracture affects an estimated 17 million Americans.4,5* WHAT IS XIAFLEX®? XIAFLEX is a prescription medicine used to treat adults with Dupuytren's contracture when a "cord" can be felt. It is not known if XIAFLEX is safe and effective in children under the age of 18. IMPORTANT SAFETY INFORMATION FOR XIAFLEX Do not receive XIAFLEX if you have had an allergic reaction to collagenase clostridium histolyticum or any of the ingredients in XIAFLEX, or to any other collagenase product. See the end of the Medication Guide for a complete list of ingredients in XIAFLEX. XIAFLEX can cause serious side effects, including: - Tendon rupture or ligament damage. Receiving an injection of XIAFLEX may cause damage to a tendon or ligament in your hand and cause it to break or weaken. This could require surgery to fix the damaged tendon or ligament. Call your healthcare provider right away if you have trouble bending your injected finger (towards the wrist) after the swelling goes down or you have problems using your treated hand after your follow-up visit
- Nerve injury or other serious injury of the hand. After finger procedures, some people developed tears in the skin (lacerations), and local skin and soft-tissue necrosis (death of skin cells). Some lacerations and necrosis required skin grafting, or other surgery including amputation. Call your healthcare provider right away if you get numbness, tingling, increased pain, or tears in the skin (laceration) in your treated finger or hand after your injection or after your follow-up visit
- Hypersensitivity reactions, including anaphylaxis. Severe allergic reactions can happen in people who receive XIAFLEX because it contains foreign proteins. Call your healthcare provider right away if you have any of these symptoms of an allergic reaction after an injection of XIAFLEX:
- hives
- swollen face
- breathing trouble
- chest pain
- low blood pressure
- dizziness or fainting
- Fainting. Fainting (passing out) or near fainting can happen in people who receive XIAFLEX, especially following finger procedures
If you have dizziness or feel faint after receiving XIAFLEX, lie down until the symptoms go away. - Increased chance of bleeding. Bleeding or bruising at the injection site can happen in people who receive XIAFLEX. Talk to your healthcare provider if you have a problem with your blood clotting. XIAFLEX may not be right for you.
Before receiving XIAFLEX, tell your healthcare provider if you have had an allergic reaction to a previous XIAFLEX injection, or have a bleeding problem or any other medical conditions. Tell your healthcare provider about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Using XIAFLEX with certain other medicines can cause serious side effects. Especially tell your healthcare provider if you take medicines to thin your blood (anticoagulants). If you are told to stop taking a blood thinner before your XIAFLEX injection, your healthcare provider should tell you when to restart the blood thinner. Ask your healthcare provider or pharmacist for a list of these medicines if you are unsure. The most common side effects with XIAFLEX for the treatment of Dupuytren's contracture include: - swelling of the injection site or the hand
- bruising or bleeding at the injection site
- pain or tenderness of the injection site or the hand
- swelling of the lymph nodes (glands) in the elbow or armpit
- itching
- breaks in the skin
- redness or warmth of the skin
- pain in the armpit
Tell your healthcare provider if you have any side effect that bothers you or does not go away. These are not all of the possible side effects with XIAFLEX. For more information, ask your healthcare provider or pharmacist. Rx Only Click for full Prescribing Information, including Medication Guide. About Endo
Endo is a diversified specialty pharmaceutical company boldly transforming insights into life-enhancing therapies. Our passionate team members collaborate to develop and deliver these essential medicines. Together, we are committed to helping everyone we serve live their best life. Learn more at www.endo.com or connect with us on LinkedIn. Cautionary Note Regarding Forward-Looking Statements
This press release contains forward-looking statements including, but not limited to, the statements by Mr. Mattice and Dr. Fanuele and any statements relating to product efficacy, potential treatments or indications, therapeutic outcomes or treatment responses, and any statements that refer to expected, estimated or anticipated future results or that do not relate solely to historical facts. Statements including words such as "believes," "expects," "anticipates," "intends," "estimates," "plan," "will," "may," "look forward," "intends," "guidance," "future," "potential" or similar expressions are forward-looking statements. Because these statements reflect Endo's current views, expectations and beliefs concerning future events, they involve risks and uncertainties, some of which Endo may not currently be able to predict. Although Endo believes that these forward-looking statements and other information are based upon reasonable assumptions and expectations, readers should not place undue reliance on these or any other forward-looking statements and information. Actual results may differ materially and adversely from current expectations based on a number of factors, including, among other things, the following: changes in competitive, market or regulatory conditions; changes in legislation or regulations; the ability to obtain and maintain adequate protection for intellectual property rights; the impacts of competition; the timing and uncertainty of the results of the research and development and the regulatory processes; health care and cost containment reforms, including government pricing, tax and reimbursement policies; litigation and other disputes; consumer and physician acceptance of current and new products; the performance of third parties upon whom we rely for goods and services; issues associated with our supply chain; the ability to develop and expand our product pipeline, to launch new products and to continue to develop the market for our products; and the effectiveness of advertising and other promotional campaigns. Endo assumes no obligation to publicly update any forward-looking statements, whether as a result of new information, future developments or otherwise, except as may be required under applicable securities laws. Additional information concerning risk factors, including those referenced above, can be found in press releases issued by Endo and in Endo's public filings with the U.S. Securities and Exchange Commission, including the discussion under the heading "Risk Factors" in Endo's most recent Form 10-K and in Endo's final prospectus filed pursuant to Rule 424(b) under the Securities Act of 1933, as amended, in connection with Endo's Form S-1/A. *Dupuytren's contracture prevalence estimation calculation: average Dupuytren's contracture prevalence in the US (5%) multiplied by US population (332 million per 2021 US Census data) = ~17 million. References - XIAFLEX® [Prescribing Information]. Rochester, MI: Endo USA, Inc.
- Hurst LC, Badalamente MA, Hentz VR, et al. N Engl J Med. 2009;361(10),968-979.
- Bayat A, McGrouther DA. Management of Dupuytren's disease--clear advice for an elusive condition. Ann R Coll Surg Engl. 2006;88(1):3-8.
- "How common is Dupuytren disease?" Dupuytren Research Group. April 1, 2017. Accessed January 13, 2025. https://dupuytrens.org/faq
- "U.S. and world population clock." U.S. Census Bureau. Updated April 13, 2023. Accessed January 13, 2025. https://www.census.gov/popclock
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SOURCE Endo, Inc. | |
