Credelio Quattro™ (lotilaner, moxidectin, praziquantel, and pyrantel chewable tablets) Kills Ticks¹ Faster² than Simparica Trio® (sarolaner, moxidectin, and pyrantel chewable tablets) and NexGard® Plus (afoxolaner, moxidectin, and pyrantel chewable tablets)
Credelio Quattro™ (lotilaner, moxidectin, praziquantel, and pyrantel chewable tablets) Kills Ticks¹ Faster² than Simparica Trio® (sarolaner, moxidectin, and pyrantel chewable tablets) and NexGard® Plus (afoxolaner, moxidectin, and pyrantel chewable tablets) |
| [22-July-2026] |
Published Data Shows that the Active Ingredient, Lotilaner, in Credelio Quattro:
INDIANAPOLIS, July 22, 2026 /PRNewswire/ -- When it comes to killing ticks, veterinarians and pet owners want it done fast. New data published in Parasites & Vectors, a leading peer-reviewed publication, demonstrates that Elanco Animal Health's (NYSE: ELAN) Credelio Quattro™ (lotilaner, moxidectin, praziquantel, and pyrantel chewable tablets) kills ticks1 faster2 than leading competitors Simparica Trio® (sarolaner, moxidectin, and pyrantel chewable tablets) and NexGard® Plus (afoxolaner, moxidectin, and pyrantel chewable tablets).i Newly Published Data Found Credelio Quattro:
"Speed of kill is a critical factor for veterinarians and pet owners when choosing parasite coverage because the longer a tick is attached, the more likely it is to transmit dangerous diseases, like Lyme disease, to pets," said Dr. Casey Locklear, veterinarian and leading parasiticides expert at Elanco. "These results reinforce that lotilaner, the active ingredient in Credelio Quattro, not only starts working fast but maintains its speed of kill4 against multiple species of ticks5, providing veterinarians and pet owners with the confidence that their dogs are protected from the very start of the month to the very end." The black-legged tick is the primary vector for Borrelia burgdorferi, the bacterium responsible for Lyme disease and anaplasmosis. The study, which evaluated the speed of kill against Ixodes scapularis (black-legged tick), found that Credelio Quattro was the only product tested to achieve significant initial tick reduction2 within just 8 hours of infestation. Notably, this rapid speed of kill1 was maintained from the beginning of the month through Day 28, providing consistent protection for the entire dosing interval.i "Ticks are on the move. They are no longer limited to the places or seasons where we have historically expected to find them," said Dr. Kathryn Reif, Bailey-Goodwin Endowed Associate Professor in Parasitology at Auburn University. "As their geographic range expands, so does the risk of tick bites and exposure to the pathogens they carry. Because tick-borne diseases can threaten the health of people, pets, and livestock, raising public awareness is more important than ever as tick populations grow and spread into new regions." The findings are based on evaluation time points at 4, 8, 12, 24, and 48 hours post-treatment and reinfestation. The data demonstrates that Credelio Quattro outperforms Simparica Trio and NexGard Plus in rapid tick1 reduction, particularly in the critical first 8 to 12 hours.i
Credelio Quattro also has a U.S. Food and Drug Administration approved claim for prevention of Lyme disease in dogs as a direct result of killing black-legged ticks. Does Credelio Quattro Kill the Lone Star Tick? Credelio Quattro is approved to protect dogs from the lone star tick (Amblyomma americanum), and its active ingredient, lotilaner, also has the fastest3 initial speed of tick kill against the lone star tick – in just 12 hours – and sustains that advantage throughout the dosing interval.ii This aggressive and expanding tick species – established across the South, Midwest and Northeast, and continuing to spread – is one of the hardest to kill and is best known for its association with alpha-gal syndrome, or the red meat allergy in humans. It can also transmit dangerous disease-causing pathogens to dogs.iii A 2024 head-to-head study published in Parasites & Vectors compared lotilaner, the active ingredient in Credelio (lotilaner) and Credelio Quattro with sarolaner in Simparica Trio and afoxolaner in NexGard®, and found that lotilaner kills the lone star tick faster4 than sarolaner in Simparica Trio and afoxolaner in NexGard, protecting dogs against this pathogen-carrying tick.
"With a heavier tick season and emergency room visits from tick bites on the riseiv, pet owners should remain vigilant and keep their pets on year-round parasite coverage," Dr. Locklear notes. "We continue to look for opportunities to make parasite protection stronger and evolve research around best-in-class medicines." Frequently Asked Questions About Ticks and Credelio Quattro: How fast does Credelio Quattro kill ticks? Studies show that lotilaner, the active ingredient in Credelio Quattro kills ticks5 faster6 than the competition.i,ii A 2026 study published in Parasites & Vectors shows that Credelio Quattro achieved significant reduction2 of black-legged ticks within 8 hours of infestation.i A 2024 study shows that lotilaner, the active ingredient in Credelio and Credelio Quattro also has the fastest3 initial speed of tick kill against the lone star tick – in just 12 hours – and sustains that advantage throughout the dosing interval.ii Why is it important to kill ticks quickly? The risk of disease transmission increases the longer a tick remains attached, making rapid speed of kill a critical factor in preventing the transmission of disease. A 2026 study shows that Credelio Quattro was the only product tested that significantly reduced2 black-legged ticks within 8 hours.i Does Credelio Quattro lose effectiveness to kill ticks1 quickly at the end of the month? No. The data shows that Credelio Quattro maintains its 8-hour speed of kill2 on Day 28, whereas competitors showed a decline in performance.i Are black-legged ticks linked to the red meat allergy in humans? In the United States, alpha-gal syndrome, or red meat allergy, is usually associated with bites from the lone star tick (Amblyomma americanum); however, two Emerging Infectious Diseases studies link bites from black-legged ticks (deer ticks) and western black-legged ticks to potentially life-threatening alpha-gal syndrome.v Additional work will be needed to determine a possible link, according to the researchers, but this continues to put emphasis on the need for tick bite protection for humans. To learn more about Credelio Quattro visit CredelioQuattroVet.com. PM-US-26-1188
NexGard and NexGard Plus are registered trademarks of Boehringer Ingelheim Animal Health USA Inc. Simparica Trio is a registered trademark of Zoetis Services LLC. Credelio Quattro, Credelio, Elanco and the diagonal bar logo are trademarks of Elanco or its affiliates. Other company and product names are trademarks of their respective owners. © 2026 Elanco or its affiliates ABOUT ELANCO Indications for Credelio Quattro/Credelio Quattro-CA1 Credelio Quattro is indicated for the prevention of heartworm disease and the treatment and control of roundworm, hookworm, and tapeworm infections. Credelio Quattro kills adult fleas and is indicated for the treatment and prevention of flea infestations and the treatment and control of tick infestations for 1 month in dogs and puppies 8 weeks of age and older and weighing 3.3 pounds or greater. Credelio Quattro is indicated for the prevention of Lyme disease infections as a direct result of killing black-legged ticks. Credelio Quattro-CA1 is conditionally approved for the treatment of infestations caused by New World screwworm (NWS) larvae in dogs and puppies 8 weeks of age and older and weighing 3.3 pounds or greater. Important Safety Information for Credelio Quattro/Credelio Quattro-CA1 Lotilaner, an ingredient in Credelio Quattro/Credelio Quattro-CA1, belongs to the isoxazoline class and has been associated with neurologic adverse reactions like tremors, incoordination, and seizures even in dogs without a history of seizures. Use with caution in dogs with a history of seizures or neurologic disorders. Dogs should be tested for existing heartworm infections before Credelio Quattro/Credelio Quattro-CA1 administration as it is not effective against adult heartworms. The safe use in breeding, pregnant, or lactating dogs has not been evaluated. The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea. Credelio Quattro-CA1 is conditionally approved by the FDA pending a full demonstration of effectiveness under application number 141-619. If you suspect that your dog is infested with NWS larvae, seek veterinary care immediately for treatment to include removal of larvae and appropriate wound care. For complete safety information, please see the Credelio Quattro/Credelio Quattro-CA1 product label or ask your veterinarian. Indications for Credelio Important Safety Information for Credelio i Reif, K.E., Kollasch, T.M., Locklear, C.L. et al. Comparative speed of kill of induced Ixodes scapularis infestations following treatment of dogs with endectocides containing either sarolaner (Simparica Trio™), afoxolaner (NexGard® PLUS), or lotilaner (Credelio Quattro™). Parasites Vectors (2026). https://doi.org/10.1186/s13071-026-07559-y Investor Contact: Tiffany Kanaga (765) 740-0314 tiffany.kanaga@elancoah.com
SOURCE Elanco Animal Health | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Company Codes: NYSE:ELAN | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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